In "The New Iberia Blues," the narrative follows Dave Robicheaux, a detective grappling with personal and professional challenges while navigating the complexities of crime and morality in Louisiana. The story intertwines his investigations with reflections on life, relationships, and the weight of one's choices. The book underscores the tension between good and evil, emphasizing how decisions shape our lives and the lives of others.

Through Robicheaux's journey, the question of the significance of major decisions is explored. Each choice he makes reflects his character and the realities he faces, prompting readers to consider how their own decisions impact their paths. This introspection amidst action serves as a reminder of the profound nature of decision-making in the human experience.