In "Extremely Loud and Incredibly Close," Jonathan Safran Foer explores themes of loss and the emotional impact of tragedy through the experience of a young boy named Oskar. Struggling with the death of his father in the September 11 attacks, Oskar embarks on a quest to uncover the meaning behind a mysterious key he found among his father's belongings. This journey represents his attempt to cope with his grief and find connection in a world full of pain.

The quote "I'd lost count of the disappointments" encapsulates Oskar's struggle with the many setbacks and emotional turmoils he faces. Throughout the story, Oskar's adventures lead to encounters that both challenge and deepen his understanding of love, loss, and hope. Each disappointment adds to his emotional burden but also spurs him on in his search, highlighting the resilience of the human spirit in the face of adversity.