The quote from Larry McMurtry's "Lonesome Dove" emphasizes the inevitability of truth coming to light. It suggests that when individuals engage in actions with the intent of keeping them secret, there is an inherent risk that the person being concealed from will eventually learn the truth. This idea reflects the universal nature of human interactions, where deception often fails to remain hidden.

Moreover, the quote speaks to the broader theme of accountability and consequences in relationships. It underscores the futility of trying to escape the repercussions of our actions, implying that dishonesty often leads to discovery and confrontation. In doing so, it highlights the importance of transparency and integrity in our dealings with others.