In the narrative of "Lonesome Dove" by Larry McMurtry, a character experiences a significant shift in his social preferences. Over the last year or two, he has developed a sense of indifference towards the company of others. This reflects a growing internal struggle or isolation, suggesting a deeper emotional or psychological change within him.

This transformation indicates that he no longer derives comfort or joy from social interactions, and instead, he finds them increasingly irritating. The change points to a profound sense of loneliness that resonates throughout the story, highlighting themes of companionship and the human condition.