The quote reflects a character's perspective on men, emphasizing that while many may be bothersome or irritating, they generally pose no serious threat. The comparison of men to chiggers and bedbugs suggests an acknowledgment of their annoyance, yet also a recognition that they are not harmful in a significant way. This viewpoint encapsulates a sense of resignation to the presence of such irritations in life.

In this way, the character's outlook illustrates a nuanced understanding of human behavior, suggesting that most men can be tolerated despite their flaws. The statement implies that overlooking their presence might be a mistake, highlighting the necessity of navigating social dynamics with a mix of acceptance and caution. This reflects broader themes within the narrative of Lonesome Dove, where relationships and interactions shape the characters' experiences in a complex world.