In "Darkness Visible," William Styron explores the profound and unsettling experience of despair. He describes it as a unique type of psychological pain that is vibrant and unyielding, setting it apart from ordinary life. This anguish, he argues, is not merely a symptom of mental illness but a distinct and consuming sensation that can permeate one’s existence, altering perceptions and feelings fundamentally.

Styron's depiction of this turmoil emphasizes its intensity and the way it can trap individuals in a cycle of distress, isolating them from those who may not understand its severity. The author illustrates how such suffering can be both enlightening and debilitating, showcasing a deep understanding of mental health and the struggles faced by those experiencing chronic anguish.