In Walter Isaacson's exploration of Leonardo da Vinci, the author reveals the deep conflict the artist faced between his visionary ideas and the limitations of his own physical abilities. Despite da Vinci's incredible talent and innovative thinking, he often felt that his hands could not fully capture the brilliance of his imagination in his artworks. This struggle highlights the tension between creative ambition and practical execution in the pursuit of perfection.

Isaacson emphasizes that while da Vinci was a master of many disciplines, the frustration he experienced when attempting to translate his grand ideas into tangible forms was a significant part of his artistic journey. This notion reflects the universal challenge faced by many creatives, where the aspiration for excellence can sometimes be hindered by the constraints of reality.