In "Chronic City," author Jonathan Lethem explores themes of heartbreak and misfortune through a unique narrative style. The phrase "It was a rebus of heartbreak, misfortune a dog could parse" suggests that the complexities of life and emotions can be interpreted and understood, even by a simple creature like a dog. This implies that the pain and struggles of life are universally recognizable, transcending human intellect.

The book delves into the intricacies of urban life and personal connections, illustrating how experiences can be both profound and perplexing. Lethem's writing captures the essence of navigating through life's challenges, making them relatable and accessible. By using a metaphor that relates to a dog's ability to understand, he emphasizes the simplicity at the core of complex emotional experiences.