In Larry McMurtry's "Lonesome Dove," the characters grapple with the challenges of adapting to the demands and rhythms of life. The narrative explores how their experiences weigh heavily on them, manifesting as a sense of weariness. Each character faces their own struggles and must navigate the complexities of their environment, which often seem overwhelming. This reflects a broader theme of the human condition, where the relentless pace of life can lead to fatigue and contemplation.

The quote highlights the emotional toll that comes with attempting to meet the various expectations and changes in life's journey. As characters traverse the rugged landscape, both physically and emotionally, they embody the universal struggle to find balance and peace amidst life's incessant demands. McMurtry captures this sentiment poignantly, illustrating how the need to adjust can leave one feeling fatigued and longing for simplicity amidst complexity.