In "Junky," William S. Burroughs explores the dual nature of addiction through the concepts of "junk sickness" and "junk kick." While the "kick" refers to the euphoric high that users experience, "junk sickness" emerges as a debilitating consequence of that dependency. This cycle reveals how addiction is all-consuming, with users trapped in a relentless pursuit of that initial high and unable to escape the negative effects that follow.

Burroughs emphasizes that individuals addicted to drugs operate within a realm shaped by their addiction, influencing both their physical and mental states. They endure a lifestyle dictated by their need for drugs, which creates a harsh environment affecting every aspect of their existence. This relationship between the euphoric and the painful highlights the profound impact of addiction, illustrating how deeply intertwined these experiences are for the junkie.