Madeleine Albright's quote emphasizes the importance of taking action, even if it can't be done universally. It suggests that individuals should not be discouraged by limitations or the inability to effect change in all areas. Instead, they should focus on making a difference where they can, recognizing that every small action contributes to a larger impact.

In Walter Isaacson's book, "American Sketches," this sentiment reflects the lives of great leaders and creative thinkers who have faced challenges in their pursuits. The stories illustrate how perseverance and targeted efforts, despite constraints, can lead to meaningful contributions and inspire others to act, reinforcing the idea that every action counts.