"Lost in the Cosmos: The Last Self-Help Book" by Walker Percy explores the paradox of human self-knowledge amidst a vast universe filled with complex phenomena. Percy highlights the irony that despite having access to countless self-help resources and mental health professionals, individuals struggle to understand their own identities. This raises questions about the nature of self-awareness and the challenges of personal introspection in an age overflowing with information.

The book emphasizes that while we can study distant cosmic objects and comprehend intricate scientific concepts, we often remain perplexed about our own existence. This juxtaposition serves to illustrate the strange and often elusive nature of self-identity. Percy's work provokes readers to reflect on their relationship with themselves, compelling them to confront the complexity of their inner worlds despite their extensive external knowledge.