In Walter Isaacson's biography "Benjamin Franklin: An American Life," the author highlights the significance of time management and the irretrievable nature of lost time through the quote, "Lost time is never found again." This sentiment reflects Franklin's belief in the importance of making the most out of every moment and the impact of time on one's life and achievements.

The quote serves as a reminder that procrastination and mismanagement of time can lead to missed opportunities that cannot be reclaimed. Franklin's life exemplifies the idea that diligence and discipline are crucial for success, encouraging readers to reflect on their use of time and pursue their goals with intention.