The quote highlights how we often overlook the subtle things that can negatively impact our perspective or our understanding. It suggests a sense of complacency in our awareness of the world around us, indicating that there are forces or events that can affect us without our real realization. This can relate to broader themes in Jeffrey Eugenides' "Middlesex," where characters encounter elements that shape their identities and life experiences in profound ways.

In "Middlesex," Eugenides explores the complexities of identity, heritage, and the hidden influences that shape who we become. The careful observation of life’s nuances and how they impact perception resonates throughout the narrative. The notion of being unaware of what may harm or alter us serves as a reminder to remain vigilant and reflective about our environments and experiences.