In Sinclair Lewis's "Main Street," the author explores the theme that institutions, rather than individuals, pose the greatest threat to personal freedom and creativity. These institutions, which can range from societal norms to familial expectations, often enforce conformity and restrain those who genuinely seek to serve or improve them. Lewis suggests that such organizations disguise their oppressive nature with seemingly noble titles, creating an illusion of legitimacy that can manipulate and control individuals.

Amid this struggle against institutional tyranny, the main character discovers that the best response is not resentment but rather an attitude of unembittered laughter. This reaction symbolizes a form of resilience and defiance, allowing individuals to navigate the challenges posed by societal structures without losing their spirit. By choosing humor, one can undermine the seriousness of oppressive institutions and maintain their autonomy and individuality in the face of conformity.