In "Dragonfly in Amber" by Diana Gabaldon, the quote reflects the shifting perception of individuals who challenge societal norms. Initially seen as witches or outsiders, such individuals often face harsh judgment and stigma from their communities. Over time, their behavior may be dismissed as madness or eccentricity, highlighting the transient nature of cultural beliefs and the way society labels those who do not conform.

This change in perception also underscores the theme of personal and cultural evolution throughout the novel. As characters grapple with their identities and the expectations of their times, the narrative illustrates how society's understanding can shift dramatically. Gabaldon's exploration of these cultural mores invites readers to question the relationship between societal acceptance and individual difference.