The quote "one flew east, one flew west, One flew over the cuckoo's nest" is a children's folk rhyme that features prominently in Ken Kesey's novel, "One Flew Over the Cuckoo's Nest." The phrase symbolizes the journey of the characters and their struggles within the confines of a mental health institution. It reflects themes of freedom, madness, and the individual versus societal norms.

In the story, the characters grapple with their identities and the oppressive systems around them. The rhyme encapsulates the dichotomy of their experiences, as they seek liberation and understanding amidst chaos, illustrating the human spirit's resilience despite confinement and societal challenges.