In "Handle with Care" by Jodi Picoult, the narrative explores the complexities of human relationships and the unpredictable nature of change. The author emphasizes that personal growth and circumstances often alter individuals, leading to surprising shifts in behavior or perspectives. This theme resonates deeply, illustrating that our understanding of others may not always be accurate.

The quote, "People changed. Even the people you thought you knew as well as you knew yourself," encapsulates the essence of this exploration. It highlights the inevitability of transformation in people, suggesting that familiarity does not guarantee an unchanging nature. This insight serves as a reminder to remain open-minded about those around us, recognizing that everyone evolves over time.