The quote from "Don Quijote de la Mancha" by Miguel de Cervantes reflects the inevitability of fate, suggesting that when misfortunes are aligned with unfavorable cosmic forces, no earthly power can prevent their impact. It highlights the futility of human efforts against the overwhelming power of destiny, indicating that some events are beyond control. This sentiment underscores the theme of resignation to fate often encountered in literature.

Cervantes emphasizes that the force of misfortune can be as unstoppable as the movement of the stars. The imagery of stars coming "from high to bass" evokes a sense of decline and struggle, suggesting that when the universe conspires against someone, personal strength and industriousness cannot alter the course set by fate. This powerful notion resonates throughout the narrative of Don Quijote, showcasing the tension between idealism and the harsh realities of life.