The characters in Jodi Picoult's "Second Glance" grapple with deep regret, illustrating that life often falls short of our desires. They each carry the weight of loss and disappointment, whether it's Ross outliving Aimee, Az mourning his deceased daughter, or Shelby struggling with her sick child. Each individual represents the universal experience of feeling let down by life's circumstances. This sense of shared anguish serves to connect them, showing that while they may feel isolated in their struggles, they are not alone in their pain.

The author emphasizes that while the burden of regret can be overwhelming, connection with others can offer a lifeline. Ross realizes that, although trapped in his personal despair, he can be rescued by the support of those who understand. This theme of interdependence highlights the importance of reaching out to others in times of crisis and collective sorrow. Ultimately, Picoult conveys the message that even amid disappointment, there remains a possibility for healing through compassion and shared experiences.