In the narrative of "Crooked Little Heart," Anne Lamott explores the complexities of human emotions through the lens of Buddhism. The protagonist grapples with the idea that desire often leads to suffering, and that love inevitably brings grief, aligning with Buddhist teachings. These concepts highlight the struggles of longing and loss, reflecting a deeper understanding of life's inherent challenges.

The quote emphasizes the connection between love and suffering, suggesting that embracing love comes with the risk of heartache. Lamott’s perspective serves as a poignant reminder that the joys of love are often intertwined with the pain of loss, illuminating the duality of human experience and the inevitability of emotional suffering in the pursuit of meaningful relationships.