In her novel "The Bean Trees," Barbara Kingsolver uses a powerful analogy to differentiate between sadness and depression. She describes sadness as a temporary and mild condition, comparable to a head cold that eventually resolves itself with time and care. This suggests that while sadness can be uncomfortable, it is a normal part of life that can be managed and will pass without lasting effects.

In contrast, Kingsolver equates depression to cancer, indicating that it is a much more serious and complex condition. Unlike sadness, depression can be debilitating and requires significant attention and treatment. This comparison highlights the importance of recognizing the severity of depression and the need for compassion and support for those who are struggling with it.