In "Calypso" by David Sedaris, the author humorously reflects on an unsettling moment where he feels the need to sanitize himself after an encounter with cancer. This moment highlights his anxiety and the often absurd lengths people go to in order to maintain some sense of cleanliness and control amidst chaos. The imagery of washing off a tumor with wet wipes serves as a metaphor for his desire to cleanse himself of fear and uncertainty.

Through this quote, Sedaris combines dark humor with an exploration of serious themes surrounding illness and mortality. It illustrates how humor can serve as a coping mechanism, enabling him to navigate his emotions in the face of life's challenges. His approach resonates with readers, making them consider their own responses to fear and vulnerability while seeking moments of levity.