The quote reflects the inherent risks associated with curiosity, suggesting that it can lead individuals down unforeseen paths. The metaphor of men living with mermaids at the bottom of the sea symbolizes the allure and potential peril of seeking knowledge or experiences beyond the ordinary. This curiosity can lead to irrevocable changes in one's life, as those who explore new realms may find themselves permanently altered or lost.

In "Oranges Are Not the Only Fruit," Jeanette Winterson explores themes of identity and self-discovery, linking curiosity to both enlightenment and danger. The idea that curious individuals might not return echoes the larger narrative of seeking one's truth, which can sometimes isolate or transform a person in profound ways. Ultimately, the quote serves as a caution about the price of exploration and the decisions we make in pursuit of our desires.