In Cormac McCarthy's "Blood Meridian," the quote reflects the mindset of individuals who perceive the world's secrets as eternally obscured. Such a perspective fosters a life filled with mystery and anxiety, indicating that a lack of understanding can lead to dread and superstition. This mindset suggests that those who believe in hidden truths may find themselves trapped in a cycle of fear and uncertainty.

McCarthy emphasizes the dangers of superstition that arise from this belief. When individuals surrender to the idea that they cannot uncover the world’s mysteries, they become vulnerable to irrational fears and misguided beliefs. The quote serves as a cautionary reminder to seek understanding rather than allowing superstition to dictate one's perception of reality.