In "The Great Partnership: Science, Religion, and the Search for Meaning," Jonathan Sacks explores the relationship between science and religion, arguing that both play essential roles in human understanding and experience. He believes that while science provides knowledge of the physical world, religion offers moral and spiritual guidance, thus creating a partnership that enriches human life.

Sacks also refers to the recent novel by his wife, Rebecca Goldstein, titled "36 Arguments for the Existence of God: A Work of Fiction." This novel reflects on philosophical debates about faith and reason, complementing Sacks's discussions on how science and religion can coexist and contribute to a deeper search for meaning in life.