The quote from William S. Burroughs, "The simplest questions are the most difficult," suggests that the basic inquiries often lead to complex challenges. This highlights how seemingly straightforward ideas can uncover deeper truths and larger implications, revealing the intricacies of thought and existence. It implies that engaging with simple questions requires profound understanding and introspection, as they often touch on fundamental aspects of life.

The context of this quote can be found in Burroughs' work, "With William Burroughs: A Report From The Bunker," where he reflects on difficult themes using simple language. His insight emphasizes the paradox that while we might expect easy answers to basic questions, the reality is far more complicated. This encourages readers to explore and embrace the complexity inherent in their inquiries.