In George Eliot's "Middlemarch," the quote emphasizes the emotional toll of encountering individuals who have extensive knowledge but lack passion or empathy. For a young and eager person, such interactions can be disheartening, highlighting the disconnect that can occur between experience and genuine engagement with life. This absence of curiosity can create a sense of isolation and frustration for those who seek deeper connections and enlightenment.

The stark contrast between youthful enthusiasm and the detached mindset of an older, knowledgeable person serves as a critique of how education and experience can sometimes lead to apathy rather than wisdom. Eliot suggests that true understanding should encompass both intellect and emotional responsiveness, indicating that a life devoid of interest can dampen the spirit of the vibrant and hopeful young individual.