Vine Deloria Jr. contrasts two approaches to understanding nature in his work, emphasizing the difference between Western science and Indigenous beliefs. He cites Roger Bacon's view that humanity can compel nature to unveil its mysteries, highlighting the aggressive, invasive tactics of Western inquiry. This perspective suggests a domination over the natural world, treating it as an object to be controlled and dissected.

In contrast, Deloria illustrates the Sioux tradition, which offers a more respectful and harmonious relationship with nature. The Sioux engage in a practice of seeking friendship and connection with the natural world, emphasizing partnership over conquest. This duality of interactions with nature reflects broader cultural philosophies, revealing how different worldviews shape humanity's relationship with the environment.