In John Irving's "A Prayer for Owen Meany," the phrase "that explains everything" is acknowledged with skepticism. The speaker conveys an understanding that such a phrase is overly simplistic in a world filled with complexity. It highlights the futility of seeking definitive answers to intricate questions and the limitations of our understanding.

This realization reflects a broader theme in the book, where characters grapple with uncertainty and the intricacies of faith, fate, and identity. Irvin suggests that while we may seek clarity, the reality is that life often defies straightforward explanations, inviting readers to embrace the ambiguity of existence.