In "An Echo in the Bone" by Diana Gabaldon, the phrase about God closing a door and opening a window takes on a darker twist. It suggests that while opportunities may arise in times of challenge, they can also come with risks and dangers. The character reflects on this metaphor and finds himself in a precarious situation, realizing that not all openings are safe or welcome. It implies a sense of anxiety about unexpected changes.

The character's skepticism about divine intervention points to a deeper commentary on life’s unpredictability. He questions whether the chances presented in moments of despair are truly beneficial or simply lead to more perilous circumstances. This highlights the struggle between finding hope in adversity and confronting the reality of their consequences.