In Henry James' book "The Ambassadors," the theme of sacrifice for the sake of others is prominently explored. The quote emphasizes that when individuals give up personal desires or possessions for someone else, they often find that they no longer feel the loss. This highlights the transformative power of altruism and the deep connections between people.

Additionally, the sentiment reflects the sense of fulfillment that comes from selfless acts. It suggests that genuine concern for others can lead to a profound sense of contentment, overshadowing what may have previously seemed important. In essence, it advocates for the value of giving and connection over materialism.