In Macbeth, the opening lines convey a sense of foreboding and mystery as the three witches discuss when they will meet again. Their gathering is associated with tumultuous weather, hinting at the chaos that will unfold throughout the play. The witches symbolize the supernatural elements that influence the fate of Macbeth and set the tone for the themes of ambition and destiny.

The quote reflects the atmosphere of uncertainty and evil that permeates the story. By linking their meetings to natural disturbances, Shakespeare emphasizes the disruption of order that accompanies the witches' prophecies. This idea foreshadows the turmoil in Macbeth's life after he encounters their predictions, illustrating how fate and personal ambition intertwine.