In Hunter S. Thompson's "Fear and Loathing in Las Vegas," he emphasizes the importance of making a powerful impact when introducing something new in a city. He advises against trivial efforts, suggesting that one should target substantial and significant experiences rather than minor distractions and insignificant matters.

Thompson's provocative quote urges individuals to pursue intensity and boldness, aiming straight for the core of experience. He implies that in a city buzzing with noise, only the most compelling actions and ideas will truly resonate and leave a mark, highlighting a preference for daring, consequential experiences over frivolous ones.