In "One Flew Over the Cuckoo's Nest," Ken Kesey explores the profound impact of suffering and the human experience. A key quote emphasizes the necessity of humor as a coping mechanism for enduring pain. It suggests that to navigate life’s challenges without succumbing to madness, individuals must find ways to laugh at their struggles and adversities. This reflects a deep understanding of the complexities of mental health and resilience.

The novel illustrates the oppressive environment within a mental institution and how humor can serve as a means of rebellion against the dehumanizing system. Kesey's characters often resort to wit and humor to assert their humanity, highlighting the transformative power of laughter in overcoming suffering. This theme resonates throughout the narrative, underlining that humor is essential for maintaining sanity amidst chaos.