In "Lovecraft Unbound," Ellen Datlow explores the complex workings of the human brain, highlighting the contrast between our advanced capabilities and the primitive instincts that still influence us. She describes the "lizard brain," a fundamental part of our mind responsible for basic functions like heartbeat regulation and heightened alertness. This primitive aspect remains active even as we experience more sophisticated emotions and awareness.

Datlow asserts that beneath the layers of human evolution and development, there exists a primitive instinctive drive that connects us to our distant ancestors, including dinosaurs. This "lizard brain" is fundamental to our survival, remaining vigilant in the face of danger even as we engage with our modern, complex existence.