The quote reflects the extreme exhaustion experienced during challenging times, particularly in stressful professions or situations. It highlights how fatigue can become so overwhelming that the only relief comes from a complete state of unconsciousness, suggesting a sense of despair and the inability to manage one's life effectively.

This notion resonates with the themes in Val McDermid's novel "Crack Down," which delves into the psychological and emotional toll of crime and investigation. The characters face intense pressures that contribute to their mental and physical fatigue, emphasizing the darker aspects of their pursuits and the personal sacrifices made in the line of duty.