In "The Grapes of Wrath," the quote reflects the idea that individuals often see themselves as more significant than they truly are, especially in the grand scheme of life and morality. The speaker points out that people can inflate their sense of self-importance through their actions, particularly through sin. However, in the eyes of the divine, these self-perceptions hold little weight.
This perspective encourages humility and reminds individuals of their place within the larger community and the universe. It suggests that despite personal struggles and ambitions, no one is so crucial that they can alter God's plan or judgment.