In Anthony Burgess's "A Clockwork Orange," there is a poignant reflection on the nature of prayer and its limits. The speaker acknowledges a profound sadness that arises from the realization that prayer may no longer hold any significance for the person being addressed.

This recognition suggests a deeper exploration of spiritual connectivity and the consequences of moving beyond the physical and emotional realms where prayer can offer solace or intervention. The statement underlines the ultimate separation that occurs when one transcends to a state where their challenges or experiences can no longer be reached through prayer.