In "When Harry Met Sally," Nora Ephron explores the complexities of male-female friendships through the characters of Harry and Sally. One significant theme is the idea that romantic attraction often complicates platonic relationships. Harry suggests that the inherent differences between genders create barriers to friendship, primarily driven by sexual tension. This perspective reflects a common belief that physical attraction can overshadow emotional connections, making it difficult for men and women to maintain a truly platonic bond.

This assertion raises questions about the nature of friendships between men and women, inviting readers to ponder whether genuine, non-sexual relationships are feasible. As Harry articulates, the "sex part" complicates interactions, implying that the potential for romance inevitably influences the dynamics of friendship. This idea serves as a focal point for the narrative, as the characters navigate their feelings and evolve, ultimately challenging their initial beliefs about love and friendship.