In "The Handmaid's Tale," Margaret Atwood explores the human tendency to grasp for significance in their lives, even in the face of overwhelming oppression. The quote highlights a profound struggle where individuals choose to engage in any activity or belief rather than confront the potentially bleak notion that their existence lacks purpose. This reflects a deep-seated fear of insignificance that drives people to cling to ideologies, rituals, or roles that provide a sense of identity and meaning.

Atwood's narrative illustrates how society can manipulate these instincts, creating environments where individuals must conform to imposed structures to find validation. Characters in the story embody this conflict as they navigate the harsh realities of their world while grappling with their innate desire for meaning. This theme resonates with broader human experiences, suggesting that the search for meaning is a fundamental part of our humanity, often overshadowed by societal expectations and existential dilemmas.