In George Eliot's "Middlemarch," the theme of isolation is prevalent among characters who find themselves in completely separate realities. Each character navigates their own experiences and emotions, often oblivious to the deeper struggles or joys that the others face. This creates a profound gap in understanding and connection, emphasizing how individuals can coexist in the same environment yet remain untouched by one another's lives.

This lack of awareness and comprehension reflects the complexity of human relationships and the barriers that can exist even in close proximity. Eliot skillfully illustrates how personal worlds can diverge significantly, leading to a sense of loneliness despite the physical closeness of people. The quote underscores the intrinsic loneliness in human experiences, suggesting that true empathy and connection are challenging to achieve.