In "Oryx and Crake" by Margaret Atwood, the distinction between expectation and desire is a significant theme. Characters often grapple with what they want versus what they realistically anticipate will happen in their lives. This disparity highlights the tension between their aspirations and the harsh realities of their world, leading to feelings of frustration and disillusionment.

Throughout the narrative, the notion that desire can fuel hope while expectation can lead to disappointment is evident. As characters navigate their complex emotions and the consequences of their choices, Atwood underscores the importance of recognizing this difference in order to cope with life's unpredictability. Understanding that not all desires will be met can lead to a deeper acceptance of one's circumstances.