In Jonathan Lethem's "A Gambler's Anatomy," the protagonist encounters a surreal blend of humor and darkness. The phrase "His ironies were ghoulish now" hints at a transformation in perspective, where what once seemed amusing has taken on a sinister tone. This shift reflects the character's journey through a world filled with unexpected twists and unsettling realizations, emphasizing the blurred lines between comedy and tragedy.

The narrative captures the complexities of life as the protagonist navigates the pitfalls of gambling, revealing deeper themes of risk, fate, and the human condition. As the story unfolds, the ghoulish ironies serve as a powerful reminder of how perceptions can change, ultimately shaping one's experience in a harsh and unpredictable reality. Lethem's exploration of these themes invites readers to reflect on their own interpretations of irony in the face of adversity.