In Margaret Atwood's "Oryx and Crake," the author reflects on the complexities of human relationships, particularly the emotional turmoil stemming from biological mismatches. She suggests that hormonal and pheromonal misalignments can lead to profound suffering, resulting in unreciprocated love and despair. This observation highlights the inherent flaws in human nature when it comes to forming lasting bonds.

Atwood captures the struggle of being imperfectly monogamous, pointing out that our biological makeup does not always align with our desires. This dissonance can create a sense of helplessness, as individuals find themselves yearning for love that may never be fully returned, underscoring the tragic aspects of human connection.