In "American Sphinx," Joseph J. Ellis explores the complexities of Thomas Jefferson's character through his letters and reflections. He recounts a specific incident that led to the disability of Jefferson's right hand, hinting at a deeper narrative filled with misfortune and folly. This experience serves as a metaphor for the unintended consequences of actions that might seem trivial at first.

Ellis emphasizes that the story of how Jefferson's hand became impaired is not just about the physical injury but also about the life choices that can lead to negative outcomes. Jefferson's acknowledgment of the folly behind his injury points to a broader commentary on human nature and the inevitability of mistakes, particularly for someone of his stature and intellect.