The speaker reflects on the frustration and futility of becoming entangled in trivial uncertainties, realizing over a lifetime that these minor perplexities are insignificant compared to profound existential questions. He suggests that obsessing over small, unclear details is ultimately less wise than pondering the existence of God or the nature of self. This realization, though comforting, comes too late to be of much benefit.

The sentiment highlights a struggle with understanding and prioritizing life's mysteries. As he acknowledges the time wasted on trivial thoughts, the speaker conveys a sense of regret, suggesting that a deeper intellectual engagement with substantial questions is more fulfilling and worthy of pursuit than fixating on fleeting ambiguities.