In Jodi Picoult's "My Sister's Keeper," the protagonist reflects on the idea that misfortune can strike repeatedly in one's life. This thought arises during a moment of vulnerability when she leans against her sister, finding a sense of comfort amidst her struggles. The metaphor of lightning suggests that one might expect to escape hardship, yet the reality is often more complex.

Izzy's response to her sister highlights a crucial lesson about agency and resilience. She suggests that some people may continue to face the same challenges due to their inability to adapt or change their situation. This exchange emphasizes the importance of recognizing when to move forward rather than remaining stagnant in the face of adversity.