In "The Yage Letters," William S. Burroughs explores the complexities of communication and understanding. He reflects on the struggle to convey deep insights or experiences to someone who may be unable or unwilling to grasp them. This theme suggests that true comprehension requires a shared context or perspective that may not be accessible to all, emphasizing the limitations of language in expressing profound experiences.

The quote highlights the frustration of attempting to share knowledge or insight with someone who is indifferent or incapable of understanding. Burroughs suggests that without a shared experience or vision, it's impossible to convey what one has truly seen or felt, underscoring the challenges of human connection and the subjective nature of perception.