In Vladimir Nabokov's "Pnin," the narrative delves into the complexities of human existence and the often-painful realities that accompany it. The quote reflects on the notion that true sincerity with oneself can lead to a disconnection from conscience, especially in a world where tragic events, like Mira's death, occur. This implies that the harshness of reality can extinguish the moral awareness and emotional understanding that typically define human consciousness.

The idea suggests that when one confronts the inevitability of suffering and loss, as seen with Mira's fate, it becomes challenging to maintain a clear sense of morality and self-awareness. This reflects a broader commentary on the human condition, suggesting that moments of profound sadness can alienate individuals from their innate sense of empathy and moral reasoning, ultimately questioning the essence of living authentically in a flawed world.